Nuclear import of the thyroid hormone receptor α1 is mediated by importin 7, importin β1, and adaptor importin α1
نویسندگان
چکیده
منابع مشابه
Importin 7 and Importin /Importin Are Nuclear Import Receptors for the Glucocorticoid Receptor
The vertebrate glucocorticoid receptor (GR) is cytoplasmic without hormone and localizes to the nucleus after hormone binding. GR has two nuclear localization signals (NLS): NL1 is similar in sequence to the SV40 NLS; NL2 is poorly defined, residing in the ligand-binding domain. We found that GR displayed similar hormone-regulated compartmentalization in Saccharomyces cerevisiae and required th...
متن کاملThe importin β / importin 7 heterodimer is a functional nuclear import receptor for histone H 1
Import of proteins into the nucleus proceeds through nuclear pore complexes and is largely mediated by nuclear transport receptors of the importin β family that use direct RanGTP-binding to regulate the interaction with their cargoes. We investigated nuclear import of the linker histone H1 and found that two receptors, importin β (Impβ) and importin 7 (Imp7, RanBP7), play a critical role in thi...
متن کاملBovine ephemeral fever rhabdovirus α1 protein has viroporin-like properties and binds importin β1 and importin 7.
Bovine ephemeral fever virus (BEFV) is an arthropod-borne rhabdovirus that is classified as the type species of the genus Ephemerovirus. In addition to the five canonical rhabdovirus structural proteins (N, P, M, G, and L), the large and complex BEFV genome contains several open reading frames (ORFs) between the G and L genes (α1, α2/α3, β, and γ) encoding proteins of unknown function. We show ...
متن کاملImportin β–Mediated Nuclear Import of Fibroblast Growth Factor Receptor
Although growth factor receptors are generally thought to carry out their role in signal transduction at the cell surface, many of these transmembrane proteins translocate to the nucleus after ligand stimulation. Here, we show that the nuclear translocation of fibroblast growth factor receptor (FGFR)1 occurs via a mechanism distinct from classical nuclear import but dependent on importin beta, ...
متن کاملImportin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons
Herpesviruses are large DNA viruses which depend on many nuclear functions, and therefore on host transport factors to ensure specific nuclear import of viral and host components. While some import cargoes bind directly to certain transport factors, most recruit importin β1 via importin α. We identified importin α1 in a small targeted siRNA screen to be important for herpes simplex virus (HSV-1...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2016
ISSN: 0303-7207
DOI: 10.1016/j.mce.2015.10.016